Multicriteria benefit-risk assessment using network meta-analysis.

نویسندگان

  • Gert van Valkenhoef
  • Tommi Tervonen
  • Jing Zhao
  • Bert de Brock
  • Hans L Hillege
  • Douwe Postmus
چکیده

OBJECTIVE To enable multicriteria benefit-risk (BR) assessment of any number of alternative treatments using all available evidence from a network of clinical trials. STUDY DESIGN AND SETTING We design a general method for multicriteria decision aiding with criteria measurements from Mixed Treatment Comparison (MTC) analyses. To evaluate the method, we apply it to BR assessment of four second-generation antidepressants and placebo in the setting of a published peer-reviewed systematic review. RESULTS The analysis without preference information shows that placebo is supported by a wide range of possible preferences. Preference information provided by a clinical expert showed that although treatment with antidepressants is warranted for severely depressed patients, for mildly depressed patients placebo is likely to be the best option. It is difficult to choose between the four antidepressants, and the results of the model indicate a high degree of uncertainty. CONCLUSIONS The designed method enables quantitative BR analysis of alternative treatments using all available evidence from a network of clinical trials. The preference-free analysis can be useful in presenting the results of an MTC considering multiple outcomes.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A benefit–risk assessment model for statins using multicriteria decision analysis based on a discrete choice experiment in Korean patients

PURPOSE The benefit-risk balance for drugs can alter post approval owing to additional data on efficacy or adverse events. This study developed a quantitative benefit-risk assessment (BRA) model for statins using multicriteria decision analysis with discrete choice experiments and compared a recent BRA with that at the time of approval. PATIENTS AND METHODS Following a systematic review of th...

متن کامل

Tenecteplase versus reteplase in acute myocardial infarction: A network meta-analysis of randomized clinical trials

Background: Acute myocardial infarction (AMI) is the leading cause of death throughout the world. One of the standard approaches to treatment of AMI is fibrinolysis. The study was conducted to evaluate the clinical efficacy of tenecteplase versus reteplase through network meta-analysis for AMI. Methods: Randomized trials were comprehensively searched in PubMed, Scopus, Cochrane library, a...

متن کامل

Tenecteplase versus reteplase in acute myocardial infarction: A network meta-analysis of randomized clinical trials

Background: Acute myocardial infarction (AMI) is the leading cause of death throughout the world. One of the standard approaches to treatment of AMI is fibrinolysis. The study was conducted to evaluate the clinical efficacy of tenecteplase versus reteplase through network meta-analysis for AMI. Methods: Randomized trials were comprehensively searched in PubMed, Scopus, Cochrane library, a...

متن کامل

Integrated assessment of biological invasions

An assessment of the consequences of biological invasions and of the measures taken against must be at the base of each social decision in this field. Three forms of uncertainty can be distinguished that make such a decision difficult to take: (1) factual uncertainty, which encompasses not only risk, but also unknown probabilities of known consequences, and unknown consequences, (2) individual ...

متن کامل

Risk Analysis of Operating Room Using the Fuzzy Bayesian Network Model

To enhance Patient’s safety, we need effective methods for risk management. This work aims to propose an integrated approach to risk management for a hospital system. To improve patient’s safety, we should develop flexible methods where different aspects of risk and type of information are taken into consideration. This paper proposes a fuzzy Bayesian network to model and analyze risk in the op...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Journal of clinical epidemiology

دوره 65 4  شماره 

صفحات  -

تاریخ انتشار 2012